In this talk, we discuss the necessity of building feedback control into synthetic circuits and present one such feedback device. We also present a new computational method to quantify the effectiveness of feedback loops in facilitating the resilience of circuits to cellular and environmental perturbations.
Hana El-Samad is the Kuo Family Endowed Professor and Vice Chair in the department of Biochemistry and Biophysics at the University of California, San Francisco and the California Institute for Quantitative Biosciences (QB3). She is a 2009 Packard Fellow and recipient of many honors including the 2011 Donald. P Eckman Award and the 2012 CSB2 prize in Systems Biology. She was also named a Paul. G. Allen Distinguished Investigator in 2013, and senior investigator of the Chan-Zuckerberg Biohub in 2017. Dr. El-Samad joined UCSF after obtaining a doctorate degree in Mechanical Engineering from the University of California, Santa Barbara, preceded by a Ms Degree in Electrical Engineering from the Iowa State University. Dr. El-Samad's research group emphasizes the role of control theory and dynamical systems in the study of biological networks. Her group works at the interface of Systems and Synthetic Biology, focusing on the architecture, roles, principles, and evolution of feedback loops in biological circuits.
For details of her research and recent publication, please visit HERE
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